Influence of admission serum albumin level on outcomes of adult patients with severe burns

Nguyen Nhu Lam1,, Nguyen Hai An1, Le Quang Thao1, Phan Quoc Khanh2
1 Le Huu Trac National Burn Hospital
2 Region 4 Military Medical Hospital

Nội dung chính của bài viết

Tóm tắt

This study aimed to detect the impact of serum albumin level at admission on the outcome of severely adult burn patients who were admitted to the Intensive care unit (ICU) within 72h after burn. The result indicated that the serum albumin level significantly reduced at admission (31.1 ± 1.1g/l). Of 62 studied patients, 10 (16.1%) patients had albumin level < 25g/l at admission. Plasma albumin level was significantly lower in patients with deep burn area  20% total body surface area, in patients who developed multiple organs failure or died (p < 0.05) and was not affected by gender, age, burn size and inhalation injury. In addition, a remarkably higher rate of multiple organ failure and death was recorded in patients with admission albumin level < 25g/l (p < 0.05). There was an insignificant relationship between admission albumin level and length of stay in the ICU, healing time of partial burn as well as a donor site.

Chi tiết bài viết

Tài liệu tham khảo

1. Ballmer P.E. (2001) Causes and mechanisms of hypoalbuminemia, Clinical Nutrition, 23(3), pp. 271 - 273.
2. Dickson P. W., Bannister D., Schreiber G. (1987) Minor burns lead to major changes in synthesis rates of plasma proteins in the liver. The Journal of trauma, 27 (3), 283-286.
3. Pérez-Guisado J., de Haro-Padilla J. M., Rioja L. F., et al. (2013) Serum albumin levels in burn people are associated with the total body surface burned and the length of hospital stay but not to the initiation of the oral/enteral nutrition. International journal of burns and trauma, 3 (3), 159.
4. Aguayo-Becerra O. A., Torres-Garibay C., Macías-Amezcua M. D., et al. (2013) Serum albumin level as a risk factor for mortality in burn patients. Clinics, 68 (7), 940-945.
5. Kim G. H., Oh K. H., Yoon J. W., et al. (2003) Impact of burn size and initial serum albumin level on acute renal failure occurring in a major burn. American journal of nephrology, 23 (1), 55-60.
6. Gong M. N., Thompson B. T., Williams P., et al. (2005) Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Critical care medicine, 33 (6), 1191-1198.
7. Gupta S., Bhattacharya S., Goyal P. (2018) The impact of first-day levels of serum proteins and lipids and their subsequent trends as prognostic indicators of burn mortality. Indian Journal of Burns, 26 (1), 48.
8. Gupta S, Bhattacharya S, Goyal P. Role of first day levels and subsequent trends of serum proteins in acute burns. J Acute Dis, 2018; 7(1):3135.