Article Sidebar

article details
Date Published: 28/02/2025
Online Published: 28/02/2025
Abstract Views: 133
Views article details: 65
DOI: https://doi.org/10.54804/yhthvb.1.2025.390
Issue
No. 1 (2025)
Section
Articles
How to Cite
Tran, D. H., Nguyen, N. L., Nguyen, T. N. M., & Dinh, T. X. (2025). Initial evaluation of Antithrombin concentration changes and predictive value for pneumonia complications in inhalation injury patients. Journal of Disaster Medicine and Burn Injuries, 1, 35-43. https://doi.org/10.54804/yhthvb.1.2025.390

Initial evaluation of Antithrombin concentration changes and predictive value for pneumonia complications in inhalation injury patients

Tran Dinh Hung1, Nguyen Nhu Lam1, Nguyen Thai Ngoc Minh1,, Dinh Thi Xuyenh2
1 Le Huu Trac National Burn Hospital
2 Vietnam - Sweden Uong Bi Hospital

Main Article Content

Abstract

Objective: Evaluate the concentration and prognostic value of antithrombin III (AT III) in serum and bronchoalveolar lavage fluid (BALF) for pneumonia complications in inhalation injury patients.
Subjects and methods: A retrospective descriptive study on 20 inhalation injury burn patients hospitalized from January 2023 to December 2023. AT III levels were quantified by ELISA at two time points: On admission and day 7 after burn. ROC curve analysis, Kaplan-Meier survival analysis and other statistical methods were used to evaluate the prognostic value of AT III.
Results: Serum AT III levels decreased significantly from day 1 (761.6 ng/mL) to day 7 (427.5 ng/ml) after burn injury (p = 0.019), while there was no significant change in AT III levels in BALF. Serum AT III levels on admission were predictive of pneumonia complications (AUC = 0.7187; p = 0.002), with an optimal cut-off value of 534.52 ng/mL, 100% sensitivity and 50% specificity. Kaplan-Meier analysis of time to pneumonia did not show a statistically significant difference between the two patient groups with AT III levels higher and lower than the predictive concentration (p = 0.3217).
Conclusion: Serum AT III levels decreased, while AT III levels in bronchoalveolar lavage fluid did not change significantly in inhalation injury burn patients. Serum AT III levels have prognostic value for pneumonia complications. Preliminary results suggest that AT III is a potential biomarker for the prognosis and treatment of pneumonia in inhalation injury patients.

Article Details

Keywords

Antithrombin III, inhalation injury, pneumonia

References

1. Kowal-Vern A., Dennis A.J., Bourdon P. et al. (2020). Bronchoalveolar lavage and plasma Antithrombin and cytokines in inhalation and burn injury: a pilot study. Int J Burns Trauma, 10(5), 255-262.
2. Enkhbaatar, P., Traber, L. D., and Traber, D. L. (2007). Antithrombin in burn trauma. In Intensive Care Medicine: Annual Update 2007 (pp. 791-796). Springer New York.
3. Niedermayr M., Schramm W., Kamolz L. et al. (2007). Antithrombin deficiency and its relationship to severe burns. Burns, 33 (2), 173-178.
4. Bravo-Pérez C., de la Morena-Barrio M.E., Vicente V. et al. (2020). Antithrombin deficiency as a still underdiagnosed thrombophilia: a primer for internists. Pol Arch Intern Med, 130 (10), 868-877.
5. Choi G., Hofstra J.-J.H., Roelofs J.J.T.H. et al. (2008). Antithrombin inhibits bronchoalveolar activation of coagulation and limits lung injury during Streptococcus pneumoniae pneumonia in rats*: Critical Care Medicine, 36(1), 204-210.
6. Natorska J., Corral J., de la Morena-Barrio M.E. et al. (2023). Antithrombin Deficiency Is Associated with Prothrombotic Plasma Fibrin Clot Phenotype. Thromb Haemost, 123 (9), 880-891.