Điều trị thành công một trường hợp viêm da mủ hoại thư

Abstract

Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis often associated with autoimmune and neoplastic diseases. Its clinical presentation is a rapidly progressive, painful skin ulcer with ill-defined borders and surrounding erythema. The exact pathogenesis of PG remains unclear but is thought to involve immune dysregulation and neutrophil dysfunction. PG frequently occurs in patients with systemic disorders, particularly inflammatory bowel disease (IBD) and arthritis. Although several diagnostic tools and validated criteria have been proposed, no universally accepted standard currently exists. There are also no standardized treatment guidelines for PG. Therapeutic strategies depend on disease severity and progression, with systemic corticosteroids, immunosuppressive agents, and biologic therapies serving as the mainstays of treatment. Appropriate wound care and management of underlying conditions are essential to optimize outcomes.