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Date Published: 20/09/2022
Online Published: 20/09/2022
Abstract Views: 310
Views Full article: 384
DOI: https://doi.org/10.54804/yhthvb.3.2022.140
Issue
No. 3 (2022)
Section
Articles
How to Cite
Vo, V. H., Nguyen, V. Q., Cao, X. D., Do, D. N., & Ninh, T. K. O. (2022). Analgesic effectiveness of Nefopam and Morphine mixture after surgery in patients with burn necrosis excision and auto-skin grafting. Journal of Disaster Medicine and Burn Injuries, 3, 14-21. https://doi.org/10.54804/yhthvb.3.2022.140

Analgesic effectiveness of Nefopam and Morphine mixture after surgery in patients with burn necrosis excision and auto-skin grafting.

Vo Van Hien1, Nguyen Van Quynh1, Cao Xuan Duong1, Do Dang Ngan2,, Ninh Thi Kim Oanh3
1 Le Huu Trac National Burn Hospital
2 Vietnam Military Medical University
3 HaNoi Medical University

Main Article Content

Abstract

Objectives: To evaluate the analgesic effectiveness of Nefopam and Morphine mixture in patients with burn necrosis excision and auto-skin grafting and its side effects.
Subjects and methods: A comparative, prospective study was conducted on 64 burnt patients who were divided into 2 groups, with an indication for necrosis excision and auto skin grafting. Postoperatively, 30 patients received continuous Morphine infusion (group M) and 34 patients received a continuous infusion of Nefopam and Morphin mixture (group N) for pain management. Evaluating analgesic levels in patients of both groups with a visual analog scale (VAS).
Results: VAS scores at rest at H0, H3, Hkt in group N were significantly lower than those in group M (2.65 ± 0.59 vs 2.90 ± 0.30; 2.53 ± 0.56 vs 2.53 ± 0.73; 2.38 ± 0.49 vs 2.90 ± 0.40) (p<0.05). VAS scores on movement at H6, H9, Hkt in group N were statistically significantly lower compared with group M (3.38 ± 0.55 vs 3.70 ± 0.70; 3.29 ± 0.46 vs 3.60 ± 0.56; 3.24 ± 0.55 vs 3.83 ± 0.37) (p < 0.05). At other times, the difference in VAS scores at rest and on movement between the two groups was statistically insignificant. The proportion of satisfied patients was high in both groups.
Conclusion: IV continuous infusion of Nefopam and Morphine mixture had good analgesic efficacy after burn necrosis excision and auto skin grafting. The satisfaction level of patients with the analgesia method was high, the side effects were mild and subtle.

Article Details

Keywords

Morphine, Nefopam, continuous infusion, burn, necrosis excision, auto-skin grafting

References

1. Summer G. J., Puntillo K. A., Miaskowski C., et al. (2007) Burn injury pain: the continuing challenge. The journal of pain, 8 (7), 533-548.
2. Meyer III W. J., Martyn J. J., Wiechman S., et al. (2018) Management of pain and other discomforts in burned patients. Total burn care, Elsevier, 679-699. e676.
3. Rudd R. A., Aleshire N., Zibbell J. E., et al. (2016) Increases in drug and opioid overdose deaths in the United States, 2000-2014. Morbidity mortality weekly report, 64 (50 & 51), 1378-1382.
4. Tramoni, G., Viale, J. P., Cazals, C., & Bhageerutty, K. (2003). Morphine-sparing effect of nefopam by continuous intravenous injection after abdominal surgery by laparotomy. European journal of anaesthesiology, 20(12), 990-992.
5. Manoir, B & Aubrun, Frédéric & Langlois, M & Guern, M & Alquier, C & Chauvin, M & Fletcher, Dominique. (2003). Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. British journal of anaesthesia. 91. 836-41. 10.1093/BJA/ aeg264.
6. Lê Hải Trung (2016) Nghiên cứu tác dụng giảm đau sau phẫu thuật cắt hoại tử bỏng và ghép da bằng morphin truyền tĩnh mạch liên tục, Luận văn bác sĩ chuyên khoa cấp 2, Học viện Quân y.
7. K. A. Grunzweig, J. Son and A. R. Kumar (2020) Regional Anesthetic Blocks for Donor Site Pain in Burn Patients: A Meta-Analysis on Efficacy, Outcomes, and Cost. Plast Surg (Oakv), 28(4), 222-231.