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The clinical effectiveness of Berberine nano gel on wound healing in rabbits.
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Abstract
Berberine is isolated from the plant Coscinium fenestratum and some plants in the family Ranunculaceae have affected wound healing and burn to heal. The research to determine the repair of full skin loss wounds of rabbits with Berberine nano gel produced by the National Burn Hospital.
Conducted on 45 rabbits, creating a skin loss of 3.5cm of diameter on each side of the rabbit's back (2 wounds/rabbit), rabbits were separated into 3 groups (15 rabbits, 30 wounds/each group).
+ Research group (Group A): Topical treatment with Berberine nano gel.
+ Control group (Group B): Topical treatment with SSD 1%.
+ Standard group (Group C): Topical treatment with 0.9% Sodium Chloride.
Keeping track of local and systemic symptoms. Results: There was no local or systemic allergic or sensitization; exudation and wound inflammation decreased more in Group A than in Groups B and C; the number of wound healing in Group A between 2 weeks and 3 weeks was higher than in Group B and Group C; The rate of re-epithelialization and the speed of epithelialization of Group A after 2 weeks were also higher than other groups.
Conclusion: Berberine nano gel for treating skin loss wounds has been demonstrated in the study to be safe, anti-inflammatory, bacteria inhibiting, and wound healing stimulating.
Article Details
Keywords
Berberine nano gel, abbit, rabbit, skin loss wound
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