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Date Published: 20/09/2022
Online Published: 20/09/2022
Abstract Views: 361
Views Full article: 355
DOI: https://doi.org/10.54804/yhthvb.3.2022.145
Issue
No. 3 (2022)
Section
Articles
How to Cite
Nguyen, N. T., Le, Q. C., & Nguyen, T. L. (2022). Study of subacute toxicology of gel nano Berberin in subclinical and pathology in Rats. Journal of Disaster Medicine and Burn Injuries, 3, 61-73. https://doi.org/10.54804/yhthvb.3.2022.145

Study of subacute toxicology of gel nano Berberin in subclinical and pathology in Rats.

Nguyen Ngoc Tuan1,, Le Quoc Chieu1, Nguyen Thuy Linh2
1 Le Huu Trac National Burn Hospital
2 Vietnam Military Medical University

Main Article Content

Abstract

Berberine is isolated from Coscinium fenestratum and several Ranunculaceae plants and it has been demonstrated to have therapeutic properties on the burn wound. The purpose of the study determined the subacute clinical toxicity of nano Berberine gel produced by the National Burn Hospital orally in rats.
Methods: The research was carried out according to The OECD 423, 2008 model. Conducted on 30 rats, divided into 3 groups, the test group administrated Dose 1 3.5g/1kg/24h, the group tested Dose 2 drank 10.5g/1kg/24h, the control group administrated distilled water Dose 10.2ml/1kg/24h. Taking the doses continuously for 28 days. Subclinical and pathological abnormalities in the livers, spleens, and kidneys were evaluated.
Results: There were no abnormal alterations in biochemical and hematological tests. There were no lesions on the microstructure of the livers, spleens, or kidneys.
Conclusion: Berberine nano gel was clinically safe when given to rats orally for 28 days between 3.5g/1kg/24h and 10.5g/1kg/24h.

Article Details

Keywords

Nano Berberine, rats, subacute toxicity

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