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Research on the effect of epidural analgesia with Levobupivacaine - Dexamethasone after major abdominal surgery
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Abstract
Objectives: To evaluate the analgesic effect of the continuous epidural infusion with Levobupivacaine - Dexamethasone after major abdominal surgery.
Subjective and Method: The method of study is a randomized controlled trial. Sixty patients undergoing major abdominal surgery were randomly allocated to two groups. The method of analgesia postoperative is levobupivacaine continuous epidural infusion with dexamethasone in group LD (n = 30) or without dexamethasone in group L (n = 30).
Results: Compared with group L, in the LD group, the onset time of effects of the charging dose was significantly earlier (7.35 ± 0.70 minutes versus 8.98 ± 1.37 minutes); the maintenance dose was significantly lower (281.70 ± 46.01 mg versus 336.90 ± 87.18 mg); the proportion of patients requiring bolus and "pain relief" doses was significantly lower (13.3% versus 43.3%); the “pain relief” dose of fentanyl was significantly lower (2.00 ± 10.95 mcg versus 25.30 ± 41.93 mcg); the resting VAS and the effort VAS were significantly lower at from the 6th hour to the 72nd hour after surgery.
Conclusion: The combination of Levobupivacaine - Dexamethasone in the continuous epidural infusion after major abdominal surgery is more effective than Levobupivacaine alone.
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Keywords
Dexamethasone, epidural analgesia, major abdominal surgery
References
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