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Đánh giá giảm đau sau phẫu thuật cắt hoại tử bỏng, ghép da bằng hỗn hợp Nefopam-Fentanyl bệnh nhân tự điều khiển đường tĩnh mạch
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Abstract
Objectives: Evaluate intravenous patient-controlled analgesia with Nefopam - Fentanyl mixture after burn necrosis excision and skin-graft surgery and the adverse effects of the therapy.
Patients and methods: A prospective study was conducted on 30 patients in the Intensive care unit (ICU) and the Adult Burn Department of Le Huu Trac National Burn Hospital from 11/2019 to 8/2020. Patients were from 16 to 60 years old with an indication surgery, with area ≥ 5% total body area; without contraindications to Nefopam and Fentanyl; without mechanical ventilation or maintaining mechanical ventilation after surgery.
Results: The average VAS at rest was always < 3 and the VAS with movement was always < 4 during the analgesia. There were not any patients who needed pain rescue with Kevindol. The very satisfying rate was 10%, the satisfied rate was 86.67% and no satisfied rate was 3.33%. The therapy was safe without respiratory and circulatory inhibition. The most common adverse effect was dry mouth (13.33%); the others included nausea and vomiting (6.67%) and itching (6.67%) and dizziness (3.33%),
Conclusion: Intravenous patient-controlled analgesia with Nefopam - Fentanyl mixture had good analgesic effectiveness and was safe after burn necrosis excision and skin graft surgery.
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Keywords
Nefopam, Fentanyl, intravenous patient-controlled analgesia, burn necrosis excision and skin-graft surgery
References
2. Rudd R. A., Aleshire N., Zibbell J. E. et al. (2016) Increases in drug and opioid overdose deaths- the United States, 2000-2014. Morbidity mortality weekly report, 64 (50 & 51), 1378-1382.
3. Nguyễn Ngọc Thạch (2020) Nghiên cứu giảm đau fentanyl đường tĩnh mạch bệnh nhân tự điều khiển sau phẫu thuật cắt hoại tử bỏng ghép da, Đề tài nghiên cứu cấp cơ sở, Học viện Quân y.
4. Trần Thanh Tuấn (2019) Nghiên cứu giảm đau 24 giờ sau phẫu thuật cắt hoại tử bỏng và ghép da bằng truyền tĩnh mạch acupan, Đề tài nghiên cứu cấp cơ sở, Bệnh viện Bỏng Quốc Gia Lê Hữu Trác.
5. Jin H. S., Kim Y. C., Yoo Y., et al. (2016) Opioid sparing effect and safety of nefopam in patient-controlled analgesia after laparotomy: A randomized, double-blind study. Journal of International Medical Research, 44 (4), 844-854.
6. Moon J. Y., Choi S. S., Lee S. Y., et al. (2016) The effect of nefopam on postoperative fentanyl consumption: a randomized, double-blind study. The Korean journal of pain, 29 (2), 110.