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Đánh giá giảm đau sau phẫu thuật cắt hoại tử bỏng, ghép da bằng hỗn hợp Nefopam-Fentanyl bệnh nhân tự điều khiển đường tĩnh mạch
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Abstract
Objectives: Evaluate intravenous patient-controlled analgesia with Nefopam - Fentanyl mixture after burn necrosis excision and skin-graft surgery and the adverse effects of the therapy.
Patients and methods: A prospective study was conducted on 30 patients in the Intensive care unit (ICU) and the Adult Burn Department of Le Huu Trac National Burn Hospital from 11/2019 to 8/2020. Patients were from 16 to 60 years old with an indication surgery, with area ≥ 5% total body area; without contraindications to Nefopam and Fentanyl; without mechanical ventilation or maintaining mechanical ventilation after surgery.
Results: The average VAS at rest was always < 3 and the VAS with movement was always < 4 during the analgesia. There were not any patients who needed pain rescue with Kevindol. The very satisfying rate was 10%, the satisfied rate was 86.67% and no satisfied rate was 3.33%. The therapy was safe without respiratory and circulatory inhibition. The most common adverse effect was dry mouth (13.33%); the others included nausea and vomiting (6.67%) and itching (6.67%) and dizziness (3.33%),
Conclusion: Intravenous patient-controlled analgesia with Nefopam - Fentanyl mixture had good analgesic effectiveness and was safe after burn necrosis excision and skin graft surgery.
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Keywords
Nefopam, Fentanyl, intravenous patient-controlled analgesia, burn necrosis excision and skin-graft surgery
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