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Date Published: 20/01/2021
Online Published: 21/03/2023
Abstract Views: 25
Views Full article: 11
Issue
No. 6 (2020)
Section
Articles
How to Cite
Nguyen, N. T., Nguyen, T. D., Nguyen, T. H., Tran, T. H., & Pham, M. Q. (2023). Evaluating the Changement of hydroxyproline (Hyp) in chronic wound tissue after treatment with platelet-rich plasma. Journal of Disaster Medicine and Burn Injuries, 6, 14-19. https://jbdmp.vn/index.php/yhthvb/article/view/202

Evaluating the Changement of hydroxyproline (Hyp) in chronic wound tissue after treatment with platelet-rich plasma

Nguyen Ngoc Tuan1,, Nguyen Tien Dung1, Nguyen Thi Huong1, Tran Thanh Hai1, Pham Minh Quyet1
1 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Background and aims: Proline hydroxylation is essential for collagen synthesis in wound healing. Therefore, hydroxyproline (Hyp quantification may be a suitable marker of wound healing in chronic wound tissue.
Material and method: This is a descriptive longitudinal study including 30 referral patients from Wound Healing Center, National Burn Hospital, from May 2019 to May 2020. Thirty patients with 33 chronic wounds were was injected subcutaneously inside and around the periphery of the chronic wound. 500mg of skin tissue from the chronic wound before and after PRP treatment were taken for the measurement of Hyp levels at the first and second of follow-up.
Results: Mean Hyp concentration in wound granulation tissue after 2 weeks of PRP treatment (3.75 ± 1.15pg/mg) was significantly higher than mean concentration in the skin before PRP treatment (2.43 ± 1.01pg/mg).
Conclusion: Our results showed that PRP therapy had a beneficial effect on wound healing of the chronic wound through the stimulation to increase Hyp.

Article Details

Keywords

Chronic wound, wound healing, hydroxyproline (Hyp)

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