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Micromorphological and immunohistochemical characteristics in chronic wounds treated by autologous platelet rich plasma
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Abstract
Objective: To describe micromorphological and immunohistochemical characteristics in chronic wounds treated by autologous platelet-rich plasma.
Subject and method: Prospective, longitudinal, observational study of 30 patients with chronic wounds in Wound Healing Center - National Burn Hospital.
Results: At time T0, images of chronic wounds have lost all the epidermis, underneath, there are many inflammatory cells, poor neovascularization, and sparse fibroblast. At time T1, inflammatory cell infiltration is significantly reduced, forming new blood vessels, although the fibrous organization has no clear structure, it is also seen that the strong growth and proliferation. At time T2, the infiltration of inflammatory cells is only very small, neoplastic blood vessels proliferate, they tend to merge into larger blood vessels to increase perfusion, the fibroblasts form a richer fibrous organization with a clear structure, arranged in bundles or collagen.
Conclusion: RPR had the effect of decreasing the inflammatory process and promoting the proliferative of fibroblast and neovascularization, leading to the reorganizing ECM structure.
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Keywords
Chronic wound, platelet-rich plasma (PRP)
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