Đánh giá tác dụng của dung dịch ABCS trên mô hình gây bỏng sâu thực nghiệm

Abstract

Objective: Investigate the model of thermal burns on white rats; evaluate the effectiveness of treating grade III skin burns (according to WHO) on an in vivo model using ABCS solution.
Subjects and Methods: The skin burn model on Wistar white rats was conducted by applying a cylindrical iron tool with contact times of 8 - 10 seconds, 18 - 20 seconds and 38 - 40 seconds respectively. Rats with degree III burns were divided into 3 groups treated with ABCS, SSD 1% cream and NaCl 0.9%. Monitor, evaluate, and collect research data on systemic and local clinical and paraclinical characteristics.
Results: Causing burns with a contact time of 39 ± 1.5 seconds to create degree III burns is appropriate to evaluate the effectiveness of ABCS in treating deep burns. Treatment with ABCS was safe, the rats’s overall condition was stable, blood tests and liver and kidney histopathology were normal. The time to completely heal third-degree burns is 28 ± 1 day. ABCS has anti-inflammatory and antibacterial effects equivalent to SSD 1% .
Conclusion: A skin burn model on white rats by applying a stainless steel cylinder filled with boiling water at 1000C with a contact time of 39 ± 1.5 seconds to create degree III skin burns (according to WHO). In vivo, ABCS is effective in treating third-degree burns, stimulates rapid wound healing, and has an antibacterial effect against common bacterial strains found in burn wounds.