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Evaluation effectiveness of hyperbaric oxygen therapy on experimental skin flaps
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Abstract
Objective: To evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on the survival of experimental skin flap.
Subjects and method: Experimental skin flaps (ratio 1:3) were created on the backs (2cm:6cm) of 10 rabbits. The experimental group received HBOT, while the control group did not.
Results: After 7 days, the experimental group treated with HBOT (6 rabbits) showed all skin flaps survived (6 flaps/6 flaps = 100%) with pink color (6 flaps/6 flaps = 100%) and increased neovascularization (6 flaps/6 flaps = 100%). In contrast, the control group (4 rabbits) without HBOT showed necrosis at the distal end of the flaps (4 flaps/4flaps = 100%).
Conclusions HBOT helps to nourish the skin flap in experimental flap transfer surgery: the skin flap periphery is pink, warm temperature, good capillary return, histopathological image increases the number of new blood vessels; experimental skin flap with a ratio of 1/3 in flap transfer surgery combined with HBOT treatment is completely alive. Using HBOT combined with nourishing experimental skin flap is safe.
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Keywords
HBOT, skin flap transfer, experimental animals
References
2. Y học dưới nước và cao áp (2010), Bài giảng Y học biển tập 2, Nhà xuất bản Y học Hà Nội
3. Fabricio Valandro Rech et al (2021), "Effect of hyperbaric oxygenation on random rat skin aps vascularization". Acta Cir Bras. 2021;36(9):e360906
4. Cristina Pires Camargo et al(2014), "Description of a new experimental model skin flap for studying skin viability in rats". March 2014.Acta Cirúrgica Brasileira 29(3):166-70, March 201429(3):166-70.DOI:10.1590/S0102-86502014000300004.
5. .Douglas Neumar et al (2017), "Effects of heparin and hyperbaric oxygenation on necrosis reduction in an animal model for degloving injuries". Rev. Col. Bras. Cir. 2017; 44(1): 064-071
6. Smriti B, Karthick G, Raja T* and Maneesh S(2024), "Role of Hyperbaric Oxygen Therapy in Salvage of Compromised Flaps". Research Article Published: 10 Feb, 2024 | Volume 8 | Issue 1 | Article 1115
7. Lee Y, Heo JW, Moon JS, Kim SW(2020), "Effects of hyperbaric oxygen on graft survival outcomes in composite grafting for amputated fingertip injury". Arch Plast Surg. 2020;47(5):444-450. doi: 10.5999/aps.2020.00381.
8. Jenwitheesuk K et al, "Degree of improvement after hyperbaric oxygen therapy for compromised flap and graft: a case series". Biom Res. 2018;29(16):3177-3180. doi: 10.4066/biomedicalresearch.29-18-663.
9. Goggins CA, Khachemoune A(2019), "The use of hyperbaric oxygen therapy in the treatment of necrotizing soft tissue infections, compromised grafts and flaps, hidradenitis suppurativa, and pyoderma gangrenosum". Acta Derm APA. 2019;28:81-84. doi: 10.15570/actaapa.2019.20
10. Rakesh Sharma, Suresh K. Sharma (2020). “Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials”. Doi: 10.1016/j.suc.2020.04.003.
11. Gammper TJ, Zhang F, Mofakhami NF. Beneficial effect hyperbaric oxygen on island flaps subjected to secondary venous ischemia. Microsurgery. 2002;22(2):49-52. doi: 10.1002/micr.21723.
12. Ulkur E, Yuksel F, Acikel C. Effect of hyperbaric oxygen on pedicle flaps with compromised circulation. Microsurgery. 2002; 22(1): 16-20. doi: 10.1002/micr.22004. [PubMed] [CrossRef] [Google Scholar]
13. Richards L, Lineaweaver WL, Stile F, Zhang F. Effect of hyperbaric oxygen therapy on the tubed pedicle flap survival in a rat model. Ann Plast Surg. 2003;50(1):51-56. doi: 10.1097/00000637-200301000-00009. [PubMed] [CrossRef] [Google Scholar]
14. A Y Sheikh et al. "Effect of hyperoxia on vascular endothelial growth factor levels in a wound model", Arch Surg. 2000 Nov. 135(11):1293-7. Doi: 10.1001/archsurg.135.11.1293.