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Date Published: 28/10/2024
Online Published: 28/10/2024
Abstract Views: 29
Views article details: 3
DOI: https://doi.org/10.54804/yhthvb.5.2024.366
Issue
No. 5 (2024)
Section
Articles
How to Cite
Nguyen, H. H., Do, D. T., & Do, X. H. (2024). Evaluate the impact of adipose-derived stem cells and their secretions on blood vessels and muscles in vivo. Journal of Disaster Medicine and Burn Injuries, 5, 74-81. https://doi.org/10.54804/yhthvb.5.2024.366

Evaluate the impact of adipose-derived stem cells and their secretions on blood vessels and muscles in vivo

Nguyen Ha Hoa1,, Do Duc Thuan1, Do Xuan Hai1
1 Vietnam Military Medical University

Main Article Content

Abstract

Objective: Evaluate the vascular and muscle-stimulating properties of adipose-derived stem cells and exosomes of adipose-derived stem cells.
Subjects and methods: Experimental study of 12 healthy adult New Zealand rabbits (1728 - 2190 g), 6 rabbits evaluated the vascular and muscle stimulation of mesenchymal stem cells (MSC), 6 rabbits evaluated the stimulation vessels and muscles of the secretome of MSC (TT). The level of vascular stimulation and muscle stimulation is based on microscopic damage of the injection area.
Results: There was mild to moderate vascular stimulation in all 3 groups with stimulation scores in the MSC group (3), the TT group (2.5) and the control group (2.7); The Average number of blood vessels in the MSC group (5), TT group (7.33), and control group (5.4); there was no inflammatory cell infiltration in muscle tissue in all 3 study groups.
Conclusion: Initial results have not shown that Adipose-derived stem cells and their exosomes stimulate blood vessels and muscles in experimental animals.

Article Details

Keywords

Vascular stimulation, muscle stimulation, mesenchymal stem cells, exosomes

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