Article Sidebar
Views Full article: 103
Study the effectiveness of autologous platelet-rich plasma (PRP) therapy on ultrastructural of a chronic wound on an electron microscope (SEM)
Main Article Content
Abstract
Objective: We aimed to characterize the ultrastructural of chronic wound response to autologous Platelet - Rich Plasma therapy (PRP).
Methods: We performed a descriptive longitudinal study at the Wound Healing Center of National Burn Hospital, from May 2019 to May 2020. Thirty patients with 33 chronic wounds were was injected subcutaneously inside and around the periphery of the chronic wound by autologous PRP. We biopsied the wound bed tissue before autologous PRP therapy, after 1 and 2 weeks of therapy process to observe the ultrastructural of chronic wounds on Scanning Electron Microscope (SEM).
Results: After autologous PRP therapy, In ultrastructural of the subcutaneous, looking at the inflammatory decreased after 1 week of therapy, and the proliferation of fibroblast and collagen fibers after 2 weeks of therapy.
Conclusion: Autologous PRP supported and promoted the wound healing of a chronic wound.
Article Details
Keywords
Chronic wound, platelet-rich plasma, ultrastructural, scanning electron microscope
References
2. Phillips T. Ulceras. In: Bolognia JL, Jorizzo JL, Rapini RP, editors. Dermatologia. 2nd ed. London: Mosby. 2008;1597-1614.
3. Lazaro JL, Izzo V, Meaume S, Davies AH, Lobmann R, Uccioli L. Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence. J Wound Care. 2016;25:277-287.
4. Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999;14:529-535.
5. Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, et al. Autologous platelet-rich plasma for treating chronic wounds. Cochrane Database Syst Rev. 2016;5:CD006899
6. Nguyễn Tiến Dũng, Đinh Văn Hân, Quản Hoàng Lâm. Nghiên cứu đặc điểm lâm sàng và vi thể vết thương mạn tính. Y dược lâm sàng 108. 2016; Tập 11- Số 5, 79-88.
7. Lisa M, Coussens, Zena Werb, Inflammation and cancer. Nature 2002;420:860-867.
8. Nguyen Ngoc Tuan, Nguyen Tien Dung et al. The Effectiveness of Platelet - Rich Plasma (PRP) on the Chronic Wound Healing Process: A Descriptive Longitudinal Study at the Wound Healing Center of National Burn Hospital. 2020; 6: 13-25.