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Date Published: 28/04/2025
Online Published: 28/04/2025
Abstract Views: 273
Views article details: 100
DOI: https://doi.org/10.54804/yhthvb.2.2025.410
Issue
No. 2 (2025)
Section
Articles
How to Cite
Ngo, M. D., Chu, A. T., & Do, X. H. (2025). Application of platelet-rich plasma from adult human blood and human umbilical cord blood in wound healing in rats: A research overview. Journal of Disaster Medicine and Burn Injuries, 2, 111-123. https://doi.org/10.54804/yhthvb.2.2025.410

Application of platelet-rich plasma from adult human blood and human umbilical cord blood in wound healing in rats: A research overview

Ngo Minh Duc1,2,, Chu Anh Tuan1,2, Do Xuan Hai1
1 Vietnam Military Medical University
2 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

This article reviews studies on the application of platelet-rich plasma (PRP) from adult human blood and umbilical cord blood in wound treatment using rat models. It focuses on analyzing the biological basis of PRP, the role of growth factors in wound healing, and comparing the composition and biological efficacy between adult-derived PRP and umbilical cord blood-derived PRP. Additionally, it examines experimental rat models, treatment outcomes (such as wound healing time, angiogenesis, granulation tissue formation), as well as current challenges and future research directions. Both adult-derived PRP and umbilical cord blood-derived PRP demonstrate significant potential for human wound treatment. Umbilical cord blood-derived PRP offers a novel approach, particularly in cases where blood collection is unfeasible, due to its rich concentration of biological factors and potential for standardized preparation. However, further direct comparative studies, protocol standardization, and long-term safety evaluations are required before widespread clinical application.

Article Details

Keywords

platelet-rich plasma, autologous blood, umbilical cord blood, wound treatment, experimental, rats

References

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