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Date Published: 02/12/2025
Online Published: 02/12/2025
Abstract Views: 99
Views article details: 15
DOI: https://doi.org/10.54804/yhthvb.6.2025.448
Issue
No. 6 (2025)
Section
Articles
How to Cite
Bùi, Đ. T., & Nguyễn, T. C. (2025). Clinical characteristics, paraclinical features, and treatment outcomes of continuous renal replacement therapy in patients with multiple organ dysfunction syndrome due to septic shock at the intensive care unit of Military Hospital 175. Journal of Disaster Medicine and Burn Injuries, 6, 29-36. https://doi.org/10.54804/yhthvb.6.2025.448

Clinical characteristics, paraclinical features, and treatment outcomes of continuous renal replacement therapy in patients with multiple organ dysfunction syndrome due to septic shock at the intensive care unit of Military Hospital 175

Bui Duc Thanh1,, Nguyen Thanh Chung2
1 175 Military Hospital
2 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Objective: To describe the clinical and paraclinical characteristics and evaluate the outcomes of continuous renal replacement therapy (CRRT) in patients with multiple organ failure due to septic shock.
Subjects and methods: This was a prospective, longitudinal, uncontrolled, cross-sectional descriptive study conducted on 47 patients diagnosed with multiple organ failure due to septic shock, treated in the Intensive Care Unit of Military Hospital 175 from June 2023 to December 2024.
Results: The study included 47 patients with multiple organ failure due to septic shock (63.8% male, mean age 58.3 ± 14.2 years), predominantly with community-acquired infections (76.6%). The mean APACHE II and SOFA scores were 22.4 ± 5.1 and 11.2 ± 3.7, respectively; mean blood lactate was 4.3 ± 2.1 mmol/L. CRRT significantly reduced the number of failed organs in the survival group (from 2.9 ± 0.9 to 1.6 ± 0.8, p < 0.001), but not in the non-survival group (p = 0.08). The shock reversal rate was 57.4%, the mortality rate was 44.7%, and the mean ICU stay was 9.5 ± 4.2 days. Early initiation of CRRT (≤ 24 hours) was associated with improved survival (64.3% vs. 21.1%, p < 0.05). Early initiation of CRRT within 24 hours was an independent protective factor (OR = 0.39; 95% CI: 0.15-0.98; p = 0.045), whereas APACHE II score (OR = 1.11; 95% CI: 1.01-1.28; p = 0.04), SOFA score (OR = 1.21; 95% CI: 1.05-1.48; p = 0.006), and blood lactate level (OR = 1.28; 95% CI: 1.04-1.68; p = 0.03) were independent risk factors.
Conclusion: Early CRRT within 24 hours is an independent protective factor that reduces the risk of mortality. In addition, APACHE II and SOFA scores, along with blood lactate levels, are independent risk factors with prognostic value for mortality in patients with septic shock.

Article Details

Keywords

Multiple organ failure, continuous renal replacement therapy, septic shock

References

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