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Date Published: 28/08/2025
Online Published: 28/08/2025
Abstract Views: 156
Views article details: 24
DOI: https://doi.org/10.54804/yhthvb.4.2025.475
Issue
No. 4 (2025)
Section
Articles
How to Cite
Le, Q. T., Tran, D. H., & Nguyen, C. T. (2025). Assessment of the topical efficacy of 2.5% Mafenide Acetate solution in the management of burn wounds infected with multidrug-resistant bacteria in pediatric patients. Journal of Disaster Medicine and Burn Injuries, 4, 110-117. https://doi.org/10.54804/yhthvb.4.2025.475

Assessment of the topical efficacy of 2.5% Mafenide Acetate solution in the management of burn wounds infected with multidrug-resistant bacteria in pediatric patients

Le Quang Thao1,, Tran Dinh Hung1, Nguyen Cong Tien1
1 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Objective: To evaluate the topical antibacterial efficacy of 2.5% mafenide acetate solution on burn wounds in pediatric patients infected with multidrug-resistant bacteria (MDR).
Subjects and methods: A prospective, descriptive interventional longitudinal study was conducted on 29 pediatric burn patients treated at the Intensive Care Unit - Le Huu Trac National Burn Hospital from June 2024 to June 2025. All patients were diagnosed with MDR bacterial infections at the wound site and received topical treatment with 2.5% mafenide acetate solution. Evaluation indicators included local erythema, exudation and bacterial count over time.
Results: After using 2.5% mafenide acetate solution, wound erythema and exudation decreased significantly over time. The bacterial load and positive culture rate decreased significantly (p < 0.001), with no positive cultures observed by day 14.
Conclusion: The 2.5% Mafenide acetate solution demonstrated marked topical antibacterial effectiveness on burn wounds in children with multidrug-resistant infections.

Article Details

Keywords

2.5% Mafenide acetate solution, multidrug-resistant bacteria, pediatric burn patients

References

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