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Date Published: 02/12/2025
Online Published: 02/12/2025
Abstract Views: 71
Views article details: 12
DOI: https://doi.org/10.54804/yhthvb.6.2025.534
Issue
No. 6 (2025)
Section
Articles
How to Cite
Trinh, V. T., Nguyen, N. S., Nguyen, V. T., Dinh, X. C., & Hoang, V. C. (2025). Effectiveness of autologous platelet-rich plasma in the treatment of difficult-healing pressure ulcers. Journal of Disaster Medicine and Burn Injuries, 6, 94-102. https://doi.org/10.54804/yhthvb.6.2025.534

Effectiveness of autologous platelet-rich plasma in the treatment of difficult-healing pressure ulcers

Trinh Van Thong1,, Nguyen Ngoc Son1, Nguyen Viet Thanh1, Dinh Xuan Chuong1, Hoang Van Chau1
1 Nghe An Friendship General Hospital

Main Article Content

Abstract

Objectives: To evaluate the efficacy of autologous platelet-rich plasma (PRP) in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients.
Subjects and methods: A random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPWT+PRP.
Results: The total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p < 0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p < 0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p < 0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p > 0.05).
Conclusion: In the treatment of refractory pressure injuries, PRP can accelerate wound healing, reduce wound pain, shorten the treatment cycle and improve the quality of life of patients without increasing complications.

Article Details

Keywords

Pressure ulcers, Autologous platelet-rich plasma, Quality of life

References

1. K Hickle, R Slamin, A Baez, D Sen, E Evan-Browning, H Tessier, et al. (2019). Wireless Pressure Ulcer Sensor: Validation in an Animal Model. Ann Plast Surg, 82, pp. S215-S221.
2. J Nixon. (2020). Silicone dressings for pressure ulcer prevention. Br J Dermatol, 183, pp. 200-201.
3. J Chen, J Long, D Wu, HH Liu. (2020). The preventive value of moisture exposed burn ointment combined with gel pad for pressure ulcers in prone patients. J Clin Res, 37, pp. 147-149.
4. HL Xu, JL Hao. (2018). Update and interpretation of Prevention and Treatment of Pressure Ulcers: Clinical Practice Guideline (2014 edition). Shanghai Nurs, 18, pp. 5-8.
5. H Xie, NM Peel, JP Hirdes, JW Poss, LC Gray. (2016). Validation of the interRAI Pressure Ulcer Risk Scale in Acute Care Hospitals. J Am Geriatr Soc, 64, pp. 1324-1328.
6. MR Walsh, BJ Nelson, JP Braman, B Yonke, M Obermeier, A Raja, et al. (2018). Platelet-rich plasma in fibrin matrix to augment rotator cuff repair: a prospective, single-blinded, randomized study with 2-year follow-up. J Shoulder Elbow Surg, 27, pp. 1553-1563.
7. X Wang, J Ma, Z Wang, L Xiao. (2018). The clinical efficacy of using autologous platelet-rich plasma in total hip arthroplasty: A retrospective comparative study. Medicine (Baltimore), 97.
8. T Tachibana, S Imafuku, R Irisawa, M Ohtsuka, T Kadono, H Fujiwara, et al. (2016). The wound/burn guidelines - 2: Guidelines for the diagnosis and treatment for pressure ulcers. J Dermatol, 43, pp. 469-506.
9. CY Lin, JS Hwang, WC Wang, WW Lai, WC Su, TY Wu, et al. (2019). Psychometric evaluation of the WHOQOL-BREF, Taiwan version, across five kinds of Taiwanese cancer survivors: Rasch analysis and confirmatory factor analysis. J Formos Med Assoc, 118, pp. 215-222.
10. A Elsaid, M El-Said, S Emile, M Youssef, W Khafagy, A Elshobaky. (2020). Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers. World J Surg, 44, pp. 1294-1301.
11. M Suthar, S Gupta, S Bukhari, V Ponemone. (2017). Treatment of chronic non-healing ulcers using autologous platelet rich plasma: a case series. J Biomed Sci, 24, pp. 16.
12. P Fu, T Miao, ZD Ying. (2019). Effects of autologous platelet-rich gel combined with negative pressure drainage on insulin resistance level and wound healing in diabetic foot patients. Hainan Med J, 30, pp. 448-451.
13. HY Jang, SM Myoung, JM Choe, T Kim, YP Cheon, YM Kim, et al. (2017). Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats. Yonsei Med J, 58, pp. 1195-1203.
14. BF Brasileiro, JE Van Sickels. (2019). Nasal Alar Pressure Ulcer After Orthognathic Surgery: Clinical Presentation and Preventive Recommendations. J Craniofac Surg, 30, pp. e533-e535.
15. J Liu, EG Rybakina, EA Korneva, M Noda. (2018). Effects of Derinat on ischemia-reperfusion-induced pressure ulcer mouse model. J Pharmacol Sci, 138, pp. 123-130.
16. G Zou, M Zheng, W Jia, X Xu, J Yin, DL Wang. (2014). Efficacy of platelet-rich plasma gel in the treatment of stage IV pressure ulcer. Chin J Geriatr, 33, pp. 1338-1340.
17. Nguyen Ngoc Tuan, Nguyen Tien Dung, et al. (2020). The Effectiveness of Platelet-Rich Plasma (PRP) on the Chronic Wound Healing Process: A Descriptive Longitudinal Study at the Wound Healing Center of National Burn Hospital. J Med Res, 6, pp. 13-25.
18. Nguyen Thi Bich Phuong. (2016). Evaluation of the effectiveness of autologous platelet-rich plasma therapy in the local treatment of chronic ulcers. Master's thesis, Military Medical Academy.