Assessment of the therapeutic efficacy of an advanced physical antimicrobial dressing in the management of partial-thickness burns

Nguyen Thai Ngoc Minh1,, Hoang Van Vu1
1 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Background: Partial-thickness burns are common, painful, and prone to infection. The Sorbact-DACC dressing with a bacterial-binding mechanism dressing may improve outcomes. This study evaluates its initial results.
Subjects and methods: A prospective descriptive longitudinal study was conducted in 30 patients (18 - 65 years) with partial-thickness burns (grade II and superficial grade III according to Le The Trung), total burn surface area ≤ 50%, admitted to the Intensive Care Unit (01 - 03/2025). Cutimed Sorbact dressing was applied, changed every 2 days. Pain (VAS) and wound cultures were assessed at N1, N3, N7, N14. Data were analyzed using Stata 17.0; p < 0.05 was considered statistically significant.
Results: Bacterial load among culture-positive sample increased at N3 (38.2 ± 15.5×10³ CFU/cm²) then decreased at N7 (2.3 ± 0.8) and N14 (1.5 ± 0.2) (p < 0.001). Negative culture rates were 53.3% at N7 and 70% at N14 (p < 0.05). Mean epithelialization time was 11.8 ± 3.2 days; dressing changes 4.5 ± 1.8. VAS score decreased from 7.1 ± 1.2 to 1.8 ± 0.8 (p < 0.001).
Conclusions: The Sorbact-DACC dressing showed positive initial results in controlling bacterial load, promoting wound healing, and reducing pain in partial-thickness burns. Larger controlled studies are needed.

Article Details

References

1. Yakupu A., Zhang J., Dong W., et al. (2022). The epidemiological characteristic and trends of burns globally. BMC Public Health, 22(1), 1596.
2. Nguyễn Như Lâm, Hồ Thị Xuân Hương, Chu Anh Tuấn (2017). Mass burn injuries: an analysis of characteristics and outcomes in a developing country. Annals of Burns and Fire Disasters, 30(3), 210-213.
3. Wasiak J., Cleland H., Campbell F., et al. (2013). Dressings for superficial and partial thickness burns. Cochrane Database of Systematic Reviews, 2013(3). Art. No.: CD002106.
4. Cutting K.F., Butcher M. (2011). DACC antimicrobial technology: a new paradigm in bioburden management. Journal of Wound Care, 20(Sup3), 1-19.
5. World Health Organization (2018). Burns fact sheet. Geneva: WHO.
6. Church D., Elsayed S., Reid O., et al. (2006). Burn Wound Infections. Clinical Microbiology Reviews, 19(2), 403-434.
7. Greenhalgh D.G. (2019). Management of Burns. New England Journal of Medicine, 380(24), 2349-2359.
8. Atiyeh B.S., Costagliola M., Hayek S.N., et al. (2007). Effect of silver on burn wound infection control and healing: review of the literature. Burns, 33(2), 139-148.
9. Barret J.P., Dziewulski P., Ramzy P.I., et al. (2000). Biobrane versus 1% silver sulfadiazine in second-degree pediatric burns. Plastic and Reconstructive Surgery, 105(1), 62-65.
10. Caruso D.M., Foster K.N., Blome-Eberwein S.A., et al. (2006). Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns. Journal of Burn Care & Research, 27(3), 298-309.
11. Mosti G., Magliaro A., Mattaliano V., et al. (2015). Comparative study of two antimicrobial dressings in infected leg ulcers: a pilot study. Journal of Wound Care, 24(3), 121-127.