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Date Published: 02/03/2020
Online Published: 11/11/2021
Abstract Views: 292
Views Full article: 215
Issue
No. 1 (2020)
Section
Articles
How to Cite
Nguyen, N. T., Lam, T. D. C., & Nguyen, V. T. (2021). Study on tolerability on healthy skin and the long-term effects on experimental animals of cellulose nano gel. Journal of Disaster Medicine and Burn Injuries, 1, 22-30. https://jbdmp.vn/index.php/yhthvb/article/view/58

Study on tolerability on healthy skin and the long-term effects on experimental animals of cellulose nano gel

Nguyen Ngoc Tuan1,, Lam Thi Dan Chi1, Nguyen Van Thinh1
1 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Nanocellulose material gained from bacteria culture has the effect of temporary wounds cover. Deer velvet contains many growth factors that are crucial for would healing process such as EGF, TGF and IGF. The Nanocellulose material combining with extraction of deer velvet (BC-A Gel) produced by the Center for High-tech Research and Development Ho Chi Minh City and Geneworld Co., Ltd meets basic standards. In order to provide the bases before clinical application, we conducted the research to assess tolerance of the product in healthy rabbit skin and its effect on long-term use in rabbits complying with the regulations of Vietnam Ministry of Health, WHO and OECD.
Results show that the product application on healthy skin does not cause irritation in which the irritation point is equal to zero. Application dose of 5g on
area of 30cm2 rabbit skin in 30 consecutive days does not cause any systemic whole-body disorder. There are not significant change (p> 0.05) in body weight, hematological and biochemical testing indicators, ECG. There are not observed histopathological lesions in liver, spleen, kidney as well.

Article Details

Keywords

Nanocellulose, deer velvet, tolerance, chronic toxicity

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