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Date Published: 26/01/2022
Online Published: 26/01/2022
Abstract Views: 385
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DOI: https://doi.org/10.54804/yhthvb.6.2021.88
Issue
No. 6 (2021)
Section
Articles
How to Cite
Nguyen, N. T., Le, Q. C., & Le, T. H. H. (2022). Acute toxicity of nano Berberine gel in white mice. Journal of Disaster Medicine and Burn Injuries, 6, 10-20. https://doi.org/10.54804/yhthvb.6.2021.88

Acute toxicity of nano Berberine gel in white mice.

Nguyen Ngoc Tuan1,, Le Quoc Chieu1, Le Thi Hong Hanh2
1 Le Huu Trac National Burn Hospital
2 Military Medical University

Main Article Content

Abstract

Berberine is isolated from Coscinium fenestratum and some plants in the family Ranunculaceae which has the effect of treating burn wounds. The study determined acute oral toxicity administration in white mice of nano Berberine gel (NBBR)  produced by the Le Huu Trac National Burns Hospital.
Research methods: The research method was accorded to the guidelines of the Ministry of Health, World Health Organization. Evaluation of 120 mice, divided into 10 groups, NBBR dosages were gradually increased from 30.9g/kg to 123.96g/kg by oral administration.
 Results: No dead mice, no abnormal disorders in movement and digestion; no abnormal histopathological found in livers, spleens and kidneys.
Conclusion: LD50 (Median Lethal Dosage) of NBBR gel had not been determined in white mice by oral administration with the highest dose that could be given 123.96g/kg body weight/day.

Article Details

Keywords

Acute toxicity, white mice, nano Berberine gel (NBBR), pathology

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