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Date Published: 06/05/2022
Online Published: 06/05/2022
Abstract Views: 511
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DOI: https://doi.org/10.54804/yhthvb.2.2022.126
Issue
No. 2 (2022)
Section
Articles
How to Cite
Nguyen, N. T., Le, Q. C., Bui, T. B. V., & Dang, V. D. (2022). Subacuteclinical toxicity of nano Berberine gel in rats. Journal of Disaster Medicine and Burn Injuries, 2, 37-45. https://doi.org/10.54804/yhthvb.2.2022.126

Subacuteclinical toxicity of nano Berberine gel in rats

Nguyen Ngoc Tuan1,, Le Quoc Chieu1, Bui Thi Bich Van2, Dang Van Diep2
1 Le Huu Trac National Burn Hospital
2 Medicine Military University

Main Article Content

Abstract

Berberine is isolated from Coscinium fenestratum and several Ranunculaceae plants and it has been demonstrated to have therapeutic properties on the burn wound. The purpose of the study determined the subacute clinical toxicity of nano berberine gel produced by the National Burn Hospital orally in rats.
Methods: The research was carried out according to the guidelines of the Ministry of Health, OECD. Conducted on 30 rats, divided into 3 groups, the test group administrated Dose 1 3.5g/1kg/24h, the group tested Dose 2 drank 10.5g/1kg/24h, the control group administrated distilled water Dose 10.2ml/1kg/24h. Take the doses continuously for 28 days.
Results: No dead rats, no abnormal movement and digestive disorders; no signs of convulsions, tremors, increased sweating, cyanosis.
Conclusion: Berberine nano gel was clinically safe when given to rats orally for 28 days between 3.5g/1kg/24h and 10.5g/1kg/24h.

Article Details

Keywords

Nano Berberine, rats, subacute toxicity

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