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Date Published: 31/08/2023
Online Published: 31/08/2023
Abstract Views: 128
Views article details: 78
DOI: https://doi.org/10.54804/yhthvb.4.2023.245
Issue
No. 4 (2023)
Section
Articles
How to Cite
Ngo, T. H., Nguyen, N. L., Nguyen, H. A., Tran, D. H., Tran, T. D. H., & Nguyen, T. M. H. (2023). Characteristics of early coagulopathy in severe burn patients. Journal of Disaster Medicine and Burn Injuries, 4, 13-19. https://doi.org/10.54804/yhthvb.4.2023.245

Characteristics of early coagulopathy in severe burn patients

Ngo Tuan Hung1,, Nguyen Nhu Lam1,2, Nguyen Hai An1,2, Tran Dinh Hung1,2, Tran Thi Diu Hien1, Nguyen Thi Mai Huong1
1 National Burn Hospital
2 Vietnam Military Medical University

Main Article Content

Abstract

Objectives: To evaluate characteristics of early coagulopathy in severe burn patients.
Subjects and methods: Retrospective study of 93 adult burn patients (16 - 65 years old), without comorbidity and trauma, with burn >= 30% of total body surface area (TBSA), hospitalized within 24 hours after burn, inpatient treatment > 3 days at the ICU, have confirmed treatment result (survival or death). Early coagulopathy in severe burn patients was defined as INR > 1.5 or aPTT > 60 s within the first 24 hours after burn.
Results: The rate of coagulopathy was 46.24%. Laboratory tests at hospitalized, PT values mainly decreased (61.29%); INR and Fibrinogen were primarily increased (73.12% and 52.69%). The group of patients with early coagulopathy had a deep burn area, the number of ventilator patients and the arterial blood lactate concentration at admission was significantly higher (p < 0.05) compared with the group without early coagulopathy; while, the temperature at admission was significantly lower (p < 0.05). The patients with early coagulopathy had a 3.5 times higher risk of early acute renal failure and a 3.2 times higher risk of death than patients without, the difference was statistically significant (p < 0.05).
Conclusion: The rate of early coagulopathy in severe burn patients is still high. Increased deep burn area, lactate and hypothermia were factors associated with early coagulopathy. Early coagulopathy was associated with complications of early acute renal failure and mortality in severe burns patients.

Article Details

Keywords

coagulopathy, severe burns

References

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