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Date Published: 31/10/2023
Online Published: 31/10/2023
Abstract Views: 62
Views article details: 49
DOI: https://doi.org/10.54804/yhthvb.5.2023.264
Issue
No. 5 (2023)
Section
Articles
How to Cite
Nguyen, T. D., & Pham, M. Q. (2023). Studying the histology changes (on H&E staining slides) of chronic wound after the autologous platelet rich plasma (PRP) therapy. Journal of Disaster Medicine and Burn Injuries, 5, 64-72. https://doi.org/10.54804/yhthvb.5.2023.264

Studying the histology changes (on H&E staining slides) of chronic wound after the autologous platelet rich plasma (PRP) therapy

Nguyen Tien Dung1,, Pham Minh Quyet1
1 National Burn Hospital

Main Article Content

Abstract

Objective: This study was to evaluate the effectiveness of local autologous Platelet Rich Plasma (PRP) on histology changes in chronic wounds.
Subjects and method: We studied 30 patients with chronic wounds, who were hospitalized at Wound Healing Center, National Burn Hospital from November 2021 to December 2022. The mean age was 57.0 ± 19.3, male/female ratio was 1.5. All patients were injected with the autologous PRP in peri-wound and wound bed once every 5 ÷ 7 days. The wound edge biopsy and H&E staining were procedure before (T1) and after the PRP injection, 7 days (T2), 14 days (T3) for evaluation of histology changes.
Results: After one week of therapy (T2): In an extracellular matrix (ECM), the inflammatory cells were significantly reduced, fibroblasts and neovascularization strongly proliferated. After two weeks of therapy (T3): Besides fibroblasts proliferation, neovascularization appearance is more dense.
Conclusion: The autologous PRP stimulated the wound healing process by helping to improve the EMC through the proliferation of fibroblasts, neovascularization, and reduction of inflammatory cells on H&E stained specimens.

Article Details

Keywords

Chronic wound, autologous Platelet Rich Plasma, histology

References

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