Nhận xét đặc điểm siêu cấu trúc của sẹo lồi trước và sau chiếu xạ bề mặt

Abstract

Objective: To evaluate some ultrastructural characteristics of keloids before and after superficial radiation therapy. 
Subjects and methods: Eight keloid samples were obtained from patients at the Vietnam National Burn Hospital, with some undergoing surgical excision alone and others receiving superficial radiation therapy (18 Gy over 3 days).
Results: In both the central and peripheral areas of the keloid still retained the general structure of the skin tissue with some changes epidermis: Irregular cell arrangement, shorter desmosomes (233 ± 7.2 nm in center vs 286 ± 6.5 nm in periphery, p < 0.05); basement membrane: reduced hemidesmosome density, irregular dermal papillae; dermis: Increased fibroblasts and collagen with abnormal structure. 
Ultrastructural characteristics of keloid after superficial radiation therapy with a lot of damage, “condensation” or “disintegration” are observed in the cells, both central and peripheral areas of the keloid. Epidermal cells were damaged at different levels. The collagen fiber bundles were arranged quite messily, the light-dark stripes of collagen fibers were not clear, and some fibers were broken. 
Conclusions: These findings highlight significant ultrastructural alterations in keloid scars, both before and after radiation therapy. Further studies with larger cohorts are needed to clarify the potential impact of X-ray therapy on keloid pathology and to determine any clinical implications.