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Date Published: 30/06/2021
Online Published: 28/09/2021
Abstract Views: 392
Views Full article: 587
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No. 3 (2021)
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Articles
How to Cite
Nguyen, D. A., Nguyen, N. T., Tran, D. T., & Pham, T. T. H. (2021). The effectiveness on prevention from nausea, vomiting and adverse effects of Granisetron after thyroid surgery. Journal of Disaster Medicine and Burn Injuries, 3, 34-41. https://jbdmp.vn/index.php/yhthvb/article/view/5

The effectiveness on prevention from nausea, vomiting and adverse effects of Granisetron after thyroid surgery

Nguyen Duc Anh1,, Nguyen Ngoc Thach2, Tran Dac Tiep2, Pham Thi Thanh Huyen3
1 Học viện Quân y
2 Bệnh viện Quân y 103
3 Bệnh viện Bạch Mai

Main Article Content

Abstract

Objectives: To evaluate the effectiveness of prevention from nausea and vomiting, adverse effects of Granisetron after thyroid surgery.
Subjects and methods: 80 cases aged 16 and over with American Society of Anaesthesiologists physical status class I or II having indications for thyroid surgery under endotracheal anesthesia were divided into two groups with 40 cases for each group Immediately before premedication, patients of each group were intravenously injected with Granisetron 1mg (group G) or Ondansetron 4mg (group O).
Results: The percentages of nausea and vomiting from 6 to 8 hours (0%), from 0 to 24 hours after surgery (5%) in group G were lower than that in group O (15% and 22.5%), respectively. The difference was statistically significant with p < 0.05. The percentages of headache, dizziness, dry mouth, constipation were 10%, 12.5%, 7.5%, 7.5%, respectively in the group G and 15%, 15%, 10%, 17.5%, respectively in group O. The difference was not statistically significant with p > 0.05.
Conclusion: Intravenous injection Granisetron had effectiveness on prevention from nausea and vomiting after thyroid surgery with low, mild, transient adverse effects.

Article Details

Keywords

Nausea and vomiting, thyroid surgery, Granisetron

References

1. Kim, S., et al., Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patient under going gynaecological surgery. British journal of anaesthesia, 2009. 103(4): p. 549-553.
2. Fujii, Y., The benefits and risks of different therapies in preventing postoperative nausea and vomiting in patients undergoing thyroid surgery. Curr Drug Saf., 2008. 3: p. 27-34.
3. Biby, M.K. and N. Veena, Comparison of ondansetron, granisetron and dexamethasone for prevention of postoperative nausea and vomiting in thyroidectomy patients in our rural tertiary care center. Journal of Evolution of Medical and Dental Sciences, 2017. 6(33): p. 2692-2697.
4. Pang, W.-W., et al., Intraoperative loading attenuates nausea and vomiting of tramadol patient-controlled analgesia. Canadian Journal of Anesthesia, 2000. 47(10): p. 968-973.
5. Apfel, C.C. and N. Roewer, Risk assessment of postoperative nausea and vomiting. Int Anesthesiol Clin, 2003. 41(4): p. 13-32.
6. Gan, T.J., et al., Consensus guidelines for managing postoperative nausea and vomiting. Anesthesia & Analgesia, 2003. 97(1): p. 62-71.
7. Nguyễn Thanh Tú, Đánh giá hiệu quả thông khí của mask thanh quản proseal trong gây mê phẫu thuật cắt gần hoàn toàn tuyến giáp. Luận văn Tốt nghiệp Bác sỹ Chuyên khoa II. Học viện Quân y, 2011.
8. Metaxari, M., et al., Antiemetic prophylaxis in thyroid surgery: a randomized, double-blind comparison of three 5-HT3 agents. J Anesth, 2011. 25(3): p. 356-62.
9. Wilson, A., et al., Single-dose iv granisetron in the prevention of postoperative nausea and vomiting. British journal of anaesthesia, 1996. 76(4): p. 515-518.
10. Barnwal, A.K., et al., Efficacy of granisetron compared to ondansetron as prophylactic antiemetic in general anaesthesia. Journal of Evolution of Medical and Dental Sciences, 2014. 3(67): p. 14458-14467.