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Evaluation of the topical therapeutic effect of Berberine nanogel on experimental
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Abstract
Objective: To evaluate the topical therapeutic effect of nano Berberine gel on an experimental burn model.
Materials and methods: 45 rabbits (90 III-degree burn zones: Superficial burn) were randomized into 3 groups: (1) 0.9% NaCl; (2) 1% silver sulfadiazine (SSD); (3) Berberine nanogel. Burns were followed for 28 days. Outcomes included systemic course, wound morphology, wound area and re-epithelialization rate, time to complete healing, and bacterial culture positivity and load.
Results: The Berberine nanogel accelerated wound area reduction compared with both controls, with a significant between-group difference emerging at week 3 (T3: 1.41 ± 1.66 cm² vs 2.98 ± 1.06 cm² with SSD; p < 0.001). Mean time to healing was markedly shorter with the nanogel (22.40 ± 3.56 days) than with SSD (27.23 ± 3.70 days) and NaCl (27.63 ± 3.92 days) (p < 0.001). On day 14, the positive culture rate was lower in the nanogel group (26.67%) than in the SSD (86.67%) and NaCl (60.0%) groups (p < 0.05).
Conclusion: In this experimental burn model, the berberine nanogel demonstrated clear topical benefits-shortening healing time, enhancing re-epithelialization, and reducing bacterial contamination-compared with SSD and NaCl, with significant differences evident from third week.
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Keywords
Berberine nanogel, Experimental burn, Topical treatment
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