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Issue: No. 3 (2026)
Section: Articles
Date Published: 28/10/2026
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How to Cite
Nguyen, Q. D., Nguyen, T. M. H., & Nguyen, T. V. (2026). Survey of microbiological etiology and antimicrobial resistancE at Le Huu Trac National Burn Hospital (2023-2026). Journal of Disaster Medicine and Burn Injuries, 3. https://jbdmp.vn/index.php/yhthvb/article/view/590

Survey of microbiological etiology and antimicrobial resistancE at Le Huu Trac National Burn Hospital (2023-2026)

Nguyen Quang Dong1, , Nguyen Thi Mai Huong1, Nguyen Thi Van1
1 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Objectives: To determine the microbiological etiology and antimicrobial resistance profiles at Le Huu Trac National Burn Hospital from January 2023 to July 2026.
Methods: A cross-sectional descriptive study was conducted on 9,369 clinical specimens (wound pus, blood, urine, sputum/ other secretions) along with standardized antimicrobial susceptibility testing (AST) analysis on 767 isolates collected between January 2023 and July 2026. Microbial identification and AST were performed using the automated Vitek 2 system (BioMérieux). Results were interpreted according to Clinical and Laboratory Standards Institute (CLSI) guidelines.
Results: 
1. The overall positive culture rate across the study period was 32.42% (3,037/9,369 specimens). Gram-negative bacilli predominated at 61.54% (1,869 isolates), followed by Gram-positive cocci at 21.70% (659 isolates) and fungi at 13.47% (409 isolates).
2. The top four leading pathogens were: Pseudomonas aeruginosa (837 isolates, 27.56%), Acinetobacter baumannii (410 isolates, 13.50%), Staphylococcus aureus (396 isolates, 13.04%), and Candida tropicalis (346 isolates, 11.39%). The Intensive Care Unit (ICU) bore the highest burden, accounting for 67.80% of all hospital-wide isolates.
3. Antimicrobial resistance profiles (evaluated on 767 isolates with AST):
- Pseudomonas aeruginosa: High resistance rates were observed for meropenem (84.86%), imipenem (86.07%), ciprofloxacin (85.26%), and cefepime (80.88%). Colistin retained strong susceptibility at 93.91% (185/197 susceptible isolates, only 1.02% resistant).
- Acinetobacter baumannii: Exhibited severe resistance, with resistance rates of 92.37% to meropenem, 91.27% to imipenem, and 92.37% to piperacillin/tazobactam.
- Staphylococcus aureus: Methicillin-resistant S. aureus (MRSA) accounted for 82.22% (74/90 isolates). Complete susceptibility (100%) was maintained against vancomycin and tigecycline, while linezolid susceptibility was 97.78%.
- Candida tropicalis: Fluconazole resistance reached 39.62% (42/106 isolates). Echinocandins (caspofungin, micafungin > 96% susceptibility) and amphotericin B (99.07% susceptibility) maintained optimal efficacy.
Conclusion: The microbiological profile at the National Burn Hospital was dominated by Gram-negative bacilli-primarily P. aeruginosa and A. baumannii-followed closely by S. aureus and the yeast C. tropicalis. The ICU concentrated the heaviest infection burden. High resistance rates were recorded across the hospital, particularly among non-fermenting Gram-negative bacilli, and azole resistance in fungal isolates.

Keywords

Severe burns, multidrug-resistant bacteria, antimicrobial susceptibility testing.

Article Details

References

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