Successful management of a multidrug-resistant bacterial surgical site infection in a traumatic amputation stump: A case report highlighting the role of multidisciplinary care
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Abstract
Surgical site infection following traumatic limb amputation is a severe complication that may result in osteomyelitis, stump necrosis, and the need for revision surgery. We report the case of a 40-year-old male patient who developed an infected left forearm amputation stump after an occupational accident. Initially, the surgical wound appeared dry and stable. However, on postoperative day 5, the wound progressively developed swelling, erythema, and serosanguinous discharge. Wound culture identified multidrug-resistant Klebsiella pneumoniae, followed subsequently by Enterococcus faecalis. Management involved a multimodal approach, including broad-spectrum antibiotic therapy guided by antimicrobial susceptibility testing, surgical debridement, and negative pressure wound therapy (NPWT/V.A.C.). After 26 days of intensive treatment, the patient was discharged with a dry, well-healed wound. This case highlights the effectiveness of close multidisciplinary collaboration among orthopedic trauma surgeons, microbiology laboratory specialists, clinical pharmacists, and nursing staff in the management of complex postoperative infections.
Keywords
surgical site infection, amputation stump, multidrug-resistant bacteria, case report
Article Details
References
2. Omoke NI, Nwigwe CG. An analysis of risk factors associated with traumatic extremity amputation stump wound infection in a Nigerian setting. Int Orthop. 2012;36(11):2327-32. doi:10.1007/s00264-012-1641-3.
3. de Godoy JMP, Ribeiro JV, Caracanhas LA, Godoy MFG. Hospital infection after major amputations. Ann Clin Microbiol Antimicrob. 2010;9:15. doi:10.1186/1476-0711-9-15.
4. Zabaglo M, Leslie SW, Sharman T. Postoperative wound infections. [Updated 2024 Mar 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560533/.
5. Ristori MV, Scarpa F, Sanna D, Casu M, Petrosillo N, Longo UG, et al. Multidrug-resistant Klebsiella pneumoniae strains in a hospital: phylogenetic analysis to investigate local epidemiology. Microorganisms. 2024;12(12):2541. doi:10.3390/microorganisms12122541.
6. Arias CA, Murray BE. The rise of the Enterococcus: beyond vancomycin resistance. Nat Rev Microbiol. 2012;10(4):266-78. doi:10.1038/nrmicro2761.
7. Ali Y, Halvorson J, Nunn A, Miller P. Delayed closure is associated with decreased infection rate in amputations after trauma. Am Surg. 2019;85(5):501-4.
8. Meehan JP. Dilute povidone-iodine irrigation: the science of molecular iodine (I2) kinetics and its antimicrobial activity. J Am Acad Orthop Surg. 2025;33:65-73. doi:10.5435/JAAOS-D-24-00471.
9. Jain A, Glass GE, Ahmadi H, Mackey S, Simmons J, Hettiaratchy S, et al. Delayed amputation following trauma increases residual lower limb infection. J Plast Reconstr Aesthet Surg. 2013;66(4):531-7. doi:10.1016/j.bjps.2012.11.026.
10. Quacinella MA, Yong TM, Obremskey WT, Stinner DJ. Negative pressure wound therapy: where are we in 2022? OTA Int. 2023;6(4 Suppl). doi:10.1097/OI9.0000000000000247.
11. Expert Working Group. Vacuum assisted closure: recommendations for use. A consensus document. Int Wound J. 2008;5 Suppl 4. doi:10.1111/j.1742-481X.2008.00537.x.
12. Dutronc H, Gobet A, Dauchy FA, Klotz R, Cazanave C, Garcia G, et al. Stump infections after major lower-limb amputation: a 10-year retrospective study. Med Mal Infect. 2013;43(11-12):456-60. doi:10.1016/j.medmal.2013.09.003.
13. Centers for Disease Control and Prevention. Isolation precautions guideline [Internet]. Atlanta (GA): CDC; 2024 [cited 2025 Sep 3]. Available from: https://www.cdc.gov/infection-control/hcp/isolation-precautions/index.html