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Evaluation of the theurapetic effect of Suporan anolyte solution on burn wounds
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Abstract
Suporan is a commercial product that is allowed to be circulated in Vietnam. It is essentially an electrochemical technology solution, it is used as a solution to wash the wound, has the effect of cleaning the wound.
Objectives: To evaluate the ability to inhibit bacteria and heal superficial burns of Suporan solution.
Subjects and research methods: Controlled clinical trial, comparing before and after treatment, comparing with 2 control drugs in pairs in the same patient. Over 30 patients with superficial burns caused by agents were treated inpatient at the Adult Burns Department - National Burn Hospital from May 2021 to September 2021.
Results: Suporan solution has an antibacterial effect on superficial burn wounds:
In vitro: Suporan solution has a sterile ring diameter with S.aureus, P. aeruginosa, E. coli, Aci. Baumannii, K. pneumoniae was stronger than 3% Betadine solution.
Clinical: The drug has the effect of preventing infection of burns equivalent to 3% Betadine solution (expression of negative culture times does not increase, the number of bacteria decreases significantly after 7 days, p < 0.05 ).
Conclusion: Suporan solution has the effect of healing burns: After 7 days of study, the drug had the effect of reducing inflammation, reducing secretions, and reducing purulent fluid more strongly than the control area treated with Betadine 3%.
The drug is safe: No pain when applied, no local and systemic allergies.
Article Details
Keywords
Electrochemical activator solution (anolite)
References
2. Nguyễn Ngọc Tuấn (2018), "Thuốc điều trị tại chỗ vết bỏng", Giáo Trình bỏng, Nhà xuất bản Quân đội Nhân dân, Tr 154-161.
3. Nguyễn Văn Hà, Nguyễn Hoài Châu. Dung dịch hoạt hóa điện hóa và ứng dụng trong y tế. Tạp chí Hóa học, tập 47, số 5A (2009), Tr 209-214.
4. Nakagawara S, Goto T, Nara M, Ozawa Y, Hotta K, Arata Y. Spectroscopic characterization and the pH dependence of bactericidal activity of the aqueous chlorine solution. Anal. Sci., 14, 691-698 (1998).
5. Huang YR, Hung YC, Hsu SY, Huang YW, Hwang DF. Application of electrolyzed water in the food industry. Food Contr., 19, 329-345 (2008).
6. Ignat Ignatov, Georgi Gluhchev, Stoil Karadzhov, Georgi Miloshev, Nikolay Ivanov, Oleg Mosin. Preparation of Electrochemically Activated Water Solutions (Catholyte/Anolyte) and Studying Their Physical-Chemical Properties. Journal of Medicine, Physiology and Biophysics, Vol. 11, 2015
7. R.M.S.Thorn, S.W.H.Lee, G.M. Robinson, J.Greenman, D.M.Reynolds. Electrochemically activated solutions: evidence for antimicrobial efficacy and applications in healthcare environments. Eur J Clin Microbiol Infect Dis, DOI 10.1007/s10096-011-1369-9, © Springer-Verlag 2011.
8. Bộ Y tế (2009), "Dược điển Việt Nam IV”, Hà Nội.
9. Vorobjeva NV, Vorobjeva LI, Khodjaev EY. The bactericidal effects of electrolyzed oxidizing water on bacterial strains involved in hospital infections. Artif. Organs, 28, 590-592 (2004).
10. J T Marais, V S Brözel. Electro-chemically activated water in dental unit water lines. British dental journal, volume 187, No.3, 1999.
11. Yu-Ru Huang, Yen Con Hung, ShunYao Hsu, Yao-Wen Huang, Deng-Fwu Hwang. Application of electrolyzed water in the food industry. Food control 19 (2008), 329-345.
12. D. Hricava, R.Stephan and C.Zweifel. Electrolyzed water and its application in the
food industry. journal of food protection, vol 71, n0.9, 2008, pages 1934-1947
13. Keramettin Yanik, Adil Karadag, Nevzat Unal, Hakan Odabasi, Saban Esen, Murat Gunaydin. An ınvestigation into the in-vitro effectiveness of electrolyzed water against various microorganisms. Int J Clin Exp Med 2015;8(7):11463-11469.
14. Robin Duncan Kirkpatrick. The mechanism of antimicrobial action of Electro-Chemically Activated (ECA) water and its healthcare applications, University of Pretoria (2009).
15. Serhan Sakarya M, Necati Gunay M, Meltem Karakulak M, Barcin Ozturk M, Bulent Ertugrul M. Hypochlorous acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Wounds, 26, 342-350 (2014).
16. Armstrong DG, Bohn G, Glat P, Kavros SJ, Kirsner R, Snyder R, Tettelbach W. Expert recommendations for the use of hypochlorous solution: Science and clinical application. Wounds, 61, 2-19 (2015).
17. Nakae H, Inaba H. Effectiveness of electrolyzed oxidized water irrigation in a burn-wound infection model. J. Trauma Acute Care Surg., 49, 511-514 (2000).
18. Mokudai T, Nakamura K et al (2012), "Presence of hydrogen peroxide, a source of hydroxyl radicals, in acid electrolyzed water”, Plos One 2012, 7: 1-8.
19. Hae Sun You, Ailyn Fadriquela, Ma Easter Joy Sajo et all (2017), Wound Healing Effect of Slightly Acidic Electrolyzed Water on Cutaneous Wounds in Hairless Mice via Immune-Redox Modulation; biological and pharmaceutical Bulletin, 2017 Volume 40 Issue 9 Pages 1423-1431.
20. Yahagi N, Kono M, Kitahara M, Ohmura A, Sumita O, Hashimoto T, Hori K, Ning-Juan C, Woodson P, Kubota S, Murakami A, Takamoto S. Effect of electrolyzed water on wound healing. Artif. Organs, 24, 984-987 (2000).
21. Xin H, Zheng Y, Hajime N, Han Z. Effect of electrolyzed oxidizing water and hydrocolloid occlusive dressings on excised burn-wounds in rats. Chin. J. Traumatol., 6, 234-237 (2003).
22. Reis R., Sipahi H., et all (2020), "Toxicity, mutagenicity and stability assessment of simply produced electrolyzed water as a wound-healing agent in vitro”, Human and experimental Toxicology, pp: 1-12.