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Date Published: 28/10/2025
Online Published: 28/10/2025
Abstract Views: 93
Views article details: 82
DOI: https://doi.org/10.54804/yhthvb.5.2025.496
Issue
No. 5 (2025)
Section
Articles
How to Cite
Ha, H. D., Le, V. T., Nguyen, T. K., Nguyen, V. T., Vo, V. H., Le, D. N., Tran, Q. T., Phan, B. D., Do, V. B., & Le, H. N. (2025). Sepsis-associated acute kidney injury. Journal of Disaster Medicine and Burn Injuries, 5, 184-189. https://doi.org/10.54804/yhthvb.5.2025.496

Sepsis-associated acute kidney injury

Ha Huy Duong1, Le Viet Thang2, Nguyen Trung Kien3, Nguyen Van Tam2, Vo Van Hien4, Le Dinh Nam1, Tran Quoc Thang1, Phan Ba Danh1, Do Van Binh1, Le Huu Nhuong1,
1 354 Military Hospital
2 103 Military Hospital
3 Military Medical Department
4 Le Huu Trac National Burn Hospital

Main Article Content

Abstract

Sepsis-associated acute kidney injury (SA-AKI) is common among critically ill patients and represents a major contributor to both disease severity and mortality. The pathophysiology is multifactorial, involving systemic and microcirculatory hemodynamic disturbances, mitochondrial dysfunction, and cellular metabolic reprogramming. Recovery following AKI depends on the balance between adaptive repair mechanisms (endothelial repair, tubular epithelial regeneration) and maladaptive repair, which predisposes patients to chronic kidney disease progression.
Current therapeutic strategies focus on early recognition and timely management of sepsis, including appropriate antimicrobial therapy, fluid resuscitation, and vasopressor support when indicated. In addition, organ support plays a pivotal role, particularly renal replacement therapy (RRT) in severe AKI, although the optimal timing and dosing of RRT remain controversial.

Article Details

Keywords

acute kidney injury, epsis-associated acute kidney injury, sepsis-induced acute kidney injury, treatment, sepsis, septic shock

References

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