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Issue: No. 5 (2025)
Section: Articles
DOI: 10.54804/yhthvb.5.2025.496
Date Published: 28/10/2025
Views 751
Downloads 183
How to Cite
Vo, V. H., Ha, H. D., Nguyen, T. K., Le, V. T., Nguyen, V. T., Le, D. N., Tran, Q. T., Phan, B. D., Do, V. B., & Le, H. N. (2025). Sepsis-associated acute kidney injury. Journal of Disaster Medicine and Burn Injuries, 5, 184-189. https://doi.org/10.54804/yhthvb.5.2025.496

Sepsis-associated acute kidney injury

Vo Van Hien1, Ha Huy Duong2, Nguyen Trung Kien3, Le Viet Thang4, Nguyen Van Tam4, Le Dinh Nam2, Tran Quoc Thang2, Phan Ba Danh2, Do Van Binh2, Le Huu Nhuong2,
1 Le Huu Trac National Burn Hospital
2 354 Military Hospital
3 Military Medical Department
4 103 Military Hospital

Main Article Content

Abstract

Sepsis-associated acute kidney injury (SA-AKI) is common among critically ill patients and represents a major contributor to both disease severity and mortality. The pathophysiology is multifactorial, involving systemic and microcirculatory hemodynamic disturbances, mitochondrial dysfunction, and cellular metabolic reprogramming. Recovery following AKI depends on the balance between adaptive repair mechanisms (endothelial repair, tubular epithelial regeneration) and maladaptive repair, which predisposes patients to chronic kidney disease progression.
Current therapeutic strategies focus on early recognition and timely management of sepsis, including appropriate antimicrobial therapy, fluid resuscitation, and vasopressor support when indicated. In addition, organ support plays a pivotal role, particularly renal replacement therapy (RRT) in severe AKI, although the optimal timing and dosing of RRT remain controversial.

Keywords

acute kidney injury, epsis-associated acute kidney injury, sepsis-induced acute kidney injury, treatment, sepsis, septic shock

Article Details

References

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